What is "ALOESIN" and what does it do?

Role: ASSETS

Family: Aloe vera active ingredient

Comedogenic index: 0

Aloesin, a compound extracted from Aloe vera, could prove effective in reducing skin hyperpigmentation.

Origins and extraction of aloesin
Aloesin is a chromone derivative with a moderately high molecular weight, extracted mainly from fresh Aloe vera leaves, but also present in other Aloe species. This natural compound is recognized for its appreciable depigmenting activity, making it a preferred choice in cosmetic and therapeutic applications aimed at lightening the skin.

Properties and mechanism of action
Potential Tyrosinase Inhibition
Aloesin may inhibit the activity of tyrosinase, an enzyme essential for melanin production. It may block two important steps in melanogenesis, reducing melanin production in cultured melanocytes.

Comparison with other agents
Studies suggest that aloesin, and similar chromones, may be more effective at inhibiting tyrosinase than arbutin or kojic acid. This supposed effectiveness is significant, given the crucial role of tyrosinase in skin pigmentation.

Benefits and prospects
Although aloesin is less able to penetrate the skin than hydroquinone, its hydrophilic nature could, according to some, offer an advantage in terms of slower penetration for cosmetic applications.

Drawing on Aloe vera's traditional use in the treatment of inflammation and skin disorders, aloesin is emerging as a potentially promising compound in the treatment of hyperpigmentation. Its ability to regulate melanin production could open up new avenues for cosmetic applications aimed at achieving clearer, more even skin.

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