NAD+: The molecule that could become your best ally in the fight against aging
The biology of skin aging has never been so closely scrutinized. And at the heart of the most recent discoveries, one factor stands out: the NAD+. Present in all our cells, this coenzyme could play a decisive role in preserving the integrity of the skin over time.
A molecule at the heart of cellular longevity
With advances in molecular biology research, one truth is becoming clear: skin aging is not only the result of sun exposure or poor lifestyle choices. It is also a direct consequence of the decline of certain key molecules within our cells. Among these is NAD+ (nicotinamide adenine dinucleotide), a universal coenzyme, is now attracting the attention of researchers for its ability to support energy metabolism, repair DNA, and regulate inflammation. These functions make it a potential player in the fight against the visible signs of skin aging.
NAD+ and cellular energy production
NAD+ participates in cellular energy production via mitochondria, it enables the conversion of nutrients into energy (ATP). With age, its concentration decreases, compromising the efficiency of cellular metabolism. This deficiency is associated with:
- A decrease in skin cell renewal,
- A slowdown in tissue repair,
- A loss of firmness and radiance in the skin.
Some studies have shown that artificially increasing NAD+ levels partially restores mitochondrial efficiency. Although these results are encouraging, the effects of topical application remain to be confirmed.
DNA repair and cellular resistance
NAD+ activates a family of enzymes called sirtuins, involved in DNA repair. These enzymes:
- Repair damage caused by oxidative stress,
- Protect the ends of chromosomes (telomeres),
- Contribute to the stability of skin cells.
This process is essential for slowing down the accumulation of mutations responsible for cellular aging. Trials show that stimulating sirtuins via NAD+ improves cell resistance to environmental stressors.
NAD+ and inflammation
Chronic inflammation is now recognized as a major factor in skin aging. NAD+ plays a role in this process, at regulated concentrations, by supporting antioxidant and anti-inflammatory mechanisms.
Topical application of NADH (reduced form of NAD+) at 1:% resulted in a marked improvement in irritation and lesions in several patients with rosacea. These results suggest that NAD+ has interesting potential in the management of skin inflammation.
Epidermal regeneration and strengthening of the skin barrier
The skin's ability to renew itself depends on the activity of the basal cells of the epidermis, a process closely linked to the availability of NAD+. It has been shown that regular application of compounds that promote NAD+ synthesis (such as myristyl nicotinate) :
- Increases the thickness of the epidermis,
- Reduces trans-epidermal water loss,
- Stimulates the synthesis of ceramides, which are essential for hydration.
These effects converge to create skin that is more resistant, better hydrated, and less prone to micro-aggressions.
NAD+, oxidative stress, and cellular protection
NAD+ acts indirectly as an antioxidant by facilitating the regeneration of other protective molecules such as glutathione. In cell models damaged by UV radiation, NAD+ supplementation:
- Reduces damage,
- Reduces inflammation rates,
- Promotes cell survival.
These properties highlight its potential role as a protector against aggressions such as UV rays and pollution.
NAD+ and its potential cosmetic applications
Several active ingredients can enhance the effectiveness of NAD+ when used topically:
- Resveratrol : Sirtuin activation
- Coenzyme Q10 : Stimulation of cell production
- Niacinamide : Strengthens the skin barrier and soothes.
