NCEF, Sleep & Peel, Time Filler - topical mesotherapy and BeautyDecoded data
Article written by Dr Sylvain David - Plastic and aesthetic surgeon - Updated: March 2026
This content is for informational and educational purposes only. It does not constitute a medical consultation. BeautyDecoded application allows you to choose cosmetics adapted to your skin type thanks to artificial intelligence.
| Product | Note BeautyDecoded | Notice (n) | Verdict |
| Sleep & Peel Night Cream | 5,00 / 5 | 1 | ~35 € - TOP AHA cream |
| NCEF Essence Lotion | 5,00 / 5 | 1 | ~40 € - TOP Japanese lotion |
| Time-Filler INTENSIVE 5XP | 5,00 / 5 | 1 | ~55 € - TOP anti-aging gel-cream |
| Cleansing oil (fragrance-free) | 4,80 / 5 | 5 | ~35 € - TOP for sensitive skin |
| Hydra-Aox Serum [5] | 4,33 / 5 | 3 | ~55 € - 5 antioxidants |
| Global-Repair Advanced Cream | 5,00 / 5 | 2 | ~65 € - Mature dry skin |
| Oxygen-Peel Lotion | 5,00 / 5 | 2 | ~30 € - Oily skin |
| Warning: Optim-Eyes Eye Contour | 2,75 / 5 | 4 | ~40 € - FLOP efficiency |
Note on BeautyDecoded reviews: the ratings and review excerpts displayed on this page come from users of the BeautyDecoded application. These reviews are not verified. Publication dates and review details are available on each product sheet.
Please note: all Filorga products are fragranced, except Perfecting Cleansing Oil. The fragrance does not contain the classic regulated allergens, but if you are sensitive to fragrance in general, please take this into account before using these products.
Founded in 1978 by Dr Michel Tordjman, Filorga has built its identity on a precise idea: to transpose the injectable mesotherapy cocktails into topical cosmetic formulas. Mesotherapy injects cocktails of vitamins, amino acids and coenzymes directly into the dermis. Filorga's liposomal technology encapsulates these hydrophilic active ingredients, enabling them to cross the skin barrier in topical application.
| NCEF assets | Documented mechanism | Clinical benefits |
| Taurine | Increased mitochondrial ATP, antioxidant | Cellular boost - red LED synergy (same mechanism) |
| Carnosine | Anti-glycation - collagen protection | Protection against sugar degradation |
| Silymarin | Antioxidant, anti-glycation, soothing | Double anti-glycation protection with carnosine |
| Liposomes | Encapsulation for enhanced penetration | Allows hydrophilic active ingredients to cross the barrier |
| 50 meso-ingredients | Vitamins, amino acids, coenzymes | Topical broad-spectrum cell nutrition |
«I don't see aesthetic medicine and skincare as opposites - the two are complementary. Filorga understood this as early as 1978. Their products don't replace medical care, but they follow the same logic: nourish the dermis with the active ingredients it needs.»
- Dr Sylvain David, Plastic Surgeon and Researcher
5/5 5.00/5 - 1 opinion BeautyDecoded | Price : ~35 € / 50 ml | Range : Sleep & Peel
BeautyDecoded algorithmic scores
| Profile / Issues | Score |
| Dry skin | 74.2 |
| Oily skin | 56.0 |
| Normal to dry skin | 81.2 |
| Normal to oily skin | 70.0 |
| Sensitive skin | -7.8 |
| Anti-aging | 79.9 |
| Imperfections | 76.5 |
| Redness | 0.0 |
| Stains | 79.9 |
Verdict Sensitivity (Dr David rule) : Not suitable for sensitive skin (score: -7.75)
Warning: AHA (glycolic acid): use 2-3 evenings/week maximum. SPF 50+ mandatory the following morning. Do not combine with retinol on the same evening. Avoid in cases of active rosacea or very reactive skin. Contraindicated during pregnancy.
Expert deciphering
Formula combining glycolic acid (majority AHA) + mandelic acid + citric acid + gluconolactone. This multi-acid blend with calibrated concentrations delivers effective exfoliation without excessive irritation - each acid acts at a different penetration speed, spreading the exfoliating effect over time. Anti-aging score: 79.9 and blemishes: 79.9 - among the highest in the Filorga catalog for these criteria.
The melting cream texture is a unique differentiator in French parapharmacy: this format combining acid exfoliation + nourishing texture is virtually impossible to find elsewhere. The galenic formula is a formulative safety feature - it glides on naturally, leading to very small application quantities, reducing the risk of overdosing.
Sensitive skin score: -7.75 - the lowest in the Filorga catalog analyzed. This score reflects the concentration of AHAs and is consistent: this product is reserved for skin that has already established tolerance to acids. Dry skin score: 74.2 and anti-imperfections score: 76.5 - versatile for a range of issues beyond pure anti-aging.
Source : Sharad J. Glycolic acid peel therapy - a current review. Clin Cosmet Investig Dermatol. 2013.
My analysis
«Sleep & Peel is the Filorga product I recommend first and foremost for confirmed anti-aging routines. A glycolic acid exfoliating cream with this galenic and this level of sensoriality, you can't find it in other marques parapharmacy products. Strict use 2-3 evenings/week. Sensitivity score of -7.75: reserved for profiles that have already tolerated AHAs.»
Verdict: TOP - Unique in French parapharmacy. AHA + melting cream texture. Limited use (2-3 evenings/week). SPF mandatory.
BeautyDecoded user reviews (1 review in total)
5/5 «I love this product and would definitely buy it again. After 1 month: soft skin, micro-wrinkles reduced. Really keeps its promises.»
5/5 5.00/5 - 1 opinion BeautyDecoded | Price : ~40 € / 150 ml | Range : NCEF
BeautyDecoded algorithmic scores
| Profile / Issues | Score |
| Dry skin | 84.0 |
| Oily skin | 84.0 |
| Normal to dry skin | 91.0 |
| Normal to oily skin | 91.0 |
| Sensitive skin | -0.6 |
| Anti-aging | 68.0 |
| Imperfections | 4.3 |
| Redness | 0.0 |
| Stains | 47.6 |
Verdict Sensitivity (Dr David rule) : Slight caution recommended (score: -0.6)
Expert deciphering
Japanese-style lotion (texture 100 % liquid, light, non-sticky) incorporating the complete NCEF complex - taurine, carnosine, silymarin, liposomes, 50 meso-ingredients transposed from injectable mesotherapy. This format is virtually absent from French parapharmacy: common in Japan and Korea (toner/essence), it provides the active ingredients of a cream in the lightness of a water.
Anti-ageing score: 68 - relevant. Taurine increases mitochondrial ATP production by stimulating respiratory chain complexes - the same mechanism as red LED photobiomodulation (633 nm). Combining this essence with the Nooance LED mask creates a documented biological synergy. Carnosine and silymarin act on glycation - an often overlooked anti-aging mechanism.
Universal scores: 84-91/100 for all skin types - profile with no skin contraindications. Sensitive skin score: -0.60 - slight caution due to the fragrance present throughout the Filorga range.
My analysis
«Essence NCEF is the most sophisticated layering lotion available in French parapharmacy. Its Japanese format + NCEF complex makes it a unique product on two levels: the galenics (not found elsewhere) and the active ingredients (mitochondrial boost + anti-glycation). Use before serum and cream to prepare skin for the active ingredients that follow.»
Verdict: TOP - Unique Japanese lotion in French para. Complete NCEF. Real synergy with red LED. Excellent quality/volume ratio.
BeautyDecoded user reviews (1 review in total)
5/5 «Excellent base before other products. Not irritating at all, helps reduce fine lines. I alternate with Time Filler essence.»
5/5 5.00/5 - 1 opinion BeautyDecoded | Price : ~55 € / 50 ml | Range : Time Filler
BeautyDecoded algorithmic scores
| Profile / Issues | Score |
| Dry skin | 80.5 |
| Oily skin | 84.0 |
| Normal to dry skin | 91.0 |
| Normal to oily skin | 91.0 |
| Sensitive skin | -0.8 |
| Anti-aging | 81.6 |
| Imperfections | 0.0 |
| Redness | 0.0 |
| Stains | 41.6 |
Verdict Sensitivity (Dr David rule) : Slight caution recommended (score: -0.75)
Expert deciphering
Formula targeting the 5 types of wrinkles (expression, deep, dry, surface, neck): multi-form hyaluronic acid base + tightening peptides + DMAE (dimethylaminoethanol, muscle acetylcholine precursor) + retinol. Retinol is present in moderate concentration - enough to contribute to cell renewal without the risks of a concentrated retinol serum. Anti-aging score: 81.6 - the highest in the Filorga catalog for this issue.
Oily skin score: 84 - the gel-cream is suitable for combination skin. Dry skin score: 80.5 - good profile. Sensitive skin score: -0.75 - slight caution due to fragrance and retinol. Melting gel-cream texture: impeccable base under make-up or SPF.
DMAE is an acetylcholine precursor that can induce a mild, temporary muscle contraction and increase skin tone. Its anti-wrinkle efficacy has been documented in vitro (Dinicolantonio JJ et al., Open Heart, 2019), with fewer clinical studies than for retinol.
My analysis
«Time-Filler 5XP is Filorga's bestseller - and deserves that status. Its anti-aging score of 81.6 is the best in the catalog. The presence of retinol implies SPF 50+ in the morning and contraindication during pregnancy. Its non-greasy, melting gel-cream texture is its main strength: it is suitable for both combination and dry skin.»
Verdict: TOP - Filorga best-seller. Maximum anti-aging score (81.6). Retinol present: SPF mandatory in the morning. Not recommended for pregnant women.
BeautyDecoded user reviews (1 review in total)
5/5 «I've been testing this anti-wrinkle serum for several days: well-moisturized skin and visible results. I really like it.»
5/5 4.80/5 - 5 opinion BeautyDecoded | Price : ~35 € / 150 ml | Range : Vinoclean
BeautyDecoded algorithmic scores
| Profile / Issues | Score |
| Dry skin | 84.0 |
| Oily skin | 0.0 |
| Normal to dry skin | 91.0 |
| Normal to oily skin | 0.0 |
| Sensitive skin | 0.0 |
| Anti-aging | 25.5 |
| Imperfections | 0.0 |
| Redness | 0.0 |
| Stains | 0.0 |
Verdict Sensitivity (Dr David rule) : Suitable for sensitive skin (score : 0)
Expert deciphering
Huile Démaquillante Perfectrice is the only Filorga product without fragrance - which sets it apart from the rest of the range. Sensitive skin score: 0 - perfectly suited. For sensitive profiles who want a Filorga product without the brand's signature fragrance, this is the preferred option.
Dry skin score: 84 and normal to dry skin score: 91 - suitable profile. Oily skin score: 0 - to be avoided on very seborrheic skin (occlusive oily formula). Confirmed cleansing effectiveness, including on sunscreens - often a limiting factor for light cleansing oils.
The special feature mentioned in the reviews: the absence of fragrance in a fully scented Filorga universe is seen as a major advantage by users reactive to fragrance. User rating: 4.80/5 out of 5 reviews - one of the best in the catalog.
My analysis
«Perfecting Cleansing Oil is the Filorga product I first recommend to fragrance-sensitive profiles - it opens up access to the brand for these profiles who reject the other products in the range. Zero sensitivity score (0). Notable exception: unpleasant haze reported on direct contact with eyes - rinse thoroughly.»
Verdict: TOP - The only fragrance-free Filorga product. Optimal sensitivity score (0). User rating 4.80/5.
BeautyDecoded user reviews (5 reviews in total)
5/5 «Atypical skin that tolerates few products: this oil is top-notch - texture, sensoriality, efficacy and UNScented. Removes make-up perfectly and doesn't dry out.»
5/5 «I love that it's fragrance-free unlike the rest of the range. Absorbs all traces of dirt. Rinses off well, moisturizes skin.»
4/5 «Effective, leaves no residue or greasy finish. Really clean skin after rinsing.»
4/5 «As a first cleanser: unpleasant film when in contact with eyes. Effective on the face.»
5/5 «Very good make-up remover, pleasant to use.»
4/5 4.33/5 - 3 opinion BeautyDecoded | Price : ~55 € / 30 ml | Range : Hydra-Aox
BeautyDecoded algorithmic scores
| Profile / Issues | Score |
| Dry skin | 87.5 |
| Oily skin | 91.0 |
| Normal to dry skin | 87.5 |
| Normal to oily skin | 91.0 |
| Sensitive skin | -1.8 |
| Anti-aging | 68.0 |
| Imperfections | 21.3 |
| Redness | 0.0 |
| Stains | 76.5 |
Verdict Sensitivity (Dr David rule) : Slight caution recommended (score: -1.75)
Expert deciphering
Complex of 5 antioxidants (vitamin C, vitamin E, niacinamide, ferulic acid, resveratrol) combined with the NCEF complex. Blemish score: 76.5 - relevant for the anti-pigmentation action of vitamin C and niacinamide. Oily skin score: 91 and dry skin score: 87.5 - universal profile for all skin types.
The combination of vitamin C + vitamin E + ferulic acid is the best documented antioxidant synergy in cosmetology (Pinnell SR et al., Dermatol Surg, 2005). Ferulic acid stabilizes vitamin C and doubles its antioxidant efficacy. Anti-aging score: 68 - relevant for preventive action.
Sensitive skin score: -1.75 - slight caution. The vitamin C concentration may cause transient tingling in reactive skin. The dosing bottle is a practical advantage for a concentrated formula: the serum lasts a long time according to feedback.
Source : Pinnell SR et al. Topical vitamin C and E synergistic. Dermatol Surg. 2005.
My analysis
«Hydra-Aox Serum [5] is the relevant option for profiles looking for a versatile antioxidant serum with NCEF as a complement. The Vit C + E + ferulic acid synergy is the best documented in the field. Spot score of 76.5: relevant for anti-pigmentation action in the morning. To be combined with SPF 50+ for daytime use.»
Verdict: - Documented antioxidant synergy (5 active ingredients). Spot score 76.5. Good bottle durability.
BeautyDecoded user reviews (3 reviews in total)
5/5 «Restores radiance, love the bottle. Good value for money as it lasts a long time.»
4/5 «Super antioxidant serum, healthy glow, lint-free, moisturizing.»
4/5 «Good, efficient surprise.»
5/5 5.00/5 - 2 reviews BeautyDecoded | Price : ~65 € / 50 ml | Range : Global Repair
BeautyDecoded algorithmic scores
| Profile / Issues | Score |
| Dry skin | 91.0 |
| Oily skin | 52.5 |
| Normal to dry skin | 91.0 |
| Normal to oily skin | 84.0 |
| Sensitive skin | -3.3 |
| Anti-aging | 68.0 |
| Imperfections | 0.0 |
| Redness | 0.0 |
| Stains | 65.5 |
Verdict Sensitivity (Dr David rule) : Warning: Not suitable for sensitive skin (score: -3.25)
Expert deciphering
Rich cream integrating the complete NCEF complex in an occlusive vehicle adapted to dry and mature skin. Dry skin score: 91 and normal to dry skin score: 91 - optimal profile. Oily skin score: 52.5 - suitable for combination skin, but too rich a texture for very seborrheic skin.
Sensitive skin score: -3.25 - slight caution, due to the complexity of the formula and the presence of fragrance. The ingredient list is long (NCEF complex = 50 meso-ingredients + cream actives) - in contrast to the minimalism of CeraVe or Avène. This is not a formulative flaw, but a deliberate choice in the Filorga philosophy.
Spot score: 65.45 - relevant for anti-pigmentation action on mature skin. User feedback (5/5 out of 2 reviews) indicates a real transformation in skin quality after several weeks, particularly on dry, post-menopausal skin.
My analysis
«Global-Repair Advanced Crème is the relevant option for mature dry skin looking for a rich night cream with NCEF cellular boost. Its maximum dry skin score (91) and blemish score (65.45) are consistent with the indication. The fragrance and the complexity of the formula are the two points of vigilance for sensitive profiles.»
Verdict: - Reference rich anti-aging cream for dry mature skin. Complete NCEF. Sensitivity score -3.25: fragrance vigilance.
BeautyDecoded user reviews (2 reviews in total)
5/5 «52 years old, dry post-menopausal skin: this cream has radically changed the quality of my skin. Good hydration, smoother, brighter, plumper skin. I'm renewing.»
4/5 «Beautiful texture but endless ingredient list and fragrance in a serious anti-aging range - lack of credibility for this formulative profile.»
3/5 2.75/5 - 4 opinion BeautyDecoded | Price : ~40 € | Range : Optim-Eyes
BeautyDecoded algorithmic scores
| Profile / Issues | Score |
| Dry skin | 84.0 |
| Oily skin | 35.0 |
| Normal to dry skin | 91.0 |
| Normal to oily skin | 70.0 |
| Sensitive skin | -0.8 |
| Anti-aging | 68.0 |
| Imperfections | 0.0 |
| Redness | 0.0 |
| Stains | 42.5 |
Verdict Sensitivity (Dr David rule) : Slight caution recommended (score: -0.75)
Expert deciphering
Optim-Eyes contains phenoxyethanol - a preservative authorized in Europe up to 1 %, with no proven risk for adults under normal conditions of use. This preservative is responsible for the reduced BeautyDecoded score (43/100) - a notable contrast with other Filorga products, which reach 86-100/100.
Anti-ageing score: 68 and spots: 42.5 - relevant for an eye contour. Sensitive skin score: -0.75 - slight caution. BeautyDecoded score: 2.75/5 out of 4 reviews - the lowest in the Filorga catalog. Feedback indicates good sensoriality but disappointing efficacy for the price.
Recommended alternative in the range: NCEF Revitalize Eyes (Global-Repair Eyes & Lips, ID 21645428, score not calculated due to lack of opinion), which contains no phenoxyethanol and incorporates the complete NCEF complex in a light, fresh gel texture.
My analysis
«Optim-Eyes is the Filorga product that disappoints the most - BeautyDecoded score of 2.75/5 (the lowest in the range), phenoxyethanol that caps the BeautyDecoded score at 43/100, and effectiveness questioned by the majority of reviews. NCEF Revitalize Eyes is a superior phenoxyethanol-free alternative in the range.»
Verdict: Warning: - Lowest rating in the catalog (2.75/5). Phenoxyethanol. Questionable efficacy. Prefer NCEF Revitalize Eyes.
BeautyDecoded user reviews (4 reviews in total)
3/5 «This is the only product that has any effect on my blue circles. No effect on fine lines - must cumulate with a second product.»
3/5 «Pleasant, good penetration, good sensoriality. No visible results despite several months of use. Price not justified.»
2/5 «Good penetration only. No results. Disappointing for the price.»
3/5 «No beneficial effect. A little more shine but nothing more. Would not use again for the price.»
5/5 5.00/5 - 2 opinion BeautyDecoded | Price : ~30 € / 150 ml | Range : Oxygen Peel
BeautyDecoded algorithmic scores
| Profile / Issues | Score |
| Dry skin | 0.0 |
| Oily skin | 84.0 |
| Normal to dry skin | 42.0 |
| Normal to oily skin | 91.0 |
| Sensitive skin | -5.8 |
| Anti-aging | 76.5 |
| Imperfections | 76.5 |
| Redness | 0.0 |
| Stains | 76.5 |
Verdict Sensitivity (Dr David rule) : Not suitable for sensitive skin (score: -5.85)
Expert deciphering
Micro-peeling lotion for oily to combination skin: score for oily skin: 84 and normal to oily skin: 91 - optimal profile. Anti-aging score: 76.5, blemishes: 76.5 and spots: 76.5 - the most balanced profile in the Filorga catalog for these three issues.
Sensitive skin score: -5.85 - not suitable for sensitive skin, consistent with the lotion's exfoliating action. Dry skin score: 0 - strictly contraindicated. This product is formulated for oily skin with imperfections looking for an exfoliant in a light daily lotion.
Perfect BeautyDecoded score (5/5 from just 2 reviews - low statistical base but consistent with formulation). Feedback confirms exfoliated skin in a single application without irritation - a positive galenic signal.
My analysis
«Oxygen-Peel is a relevant option for oily skin looking for a light lotion exfoliant with triple anti-aging / blemish / spot action. Sensitivity score -5.85: not suitable for sensitive skin. Dry skin score 0: not recommended. For sensitive skin looking for a daily exfoliant, Time Filler Essence (gluconolactone, mild PHA) is more suitable.»
Verdict: - Triple score 76.5 on anti-aging, blemishes and spots. Optimal profile for oily skin. Not recommended for dry and sensitive skin.
BeautyDecoded user reviews (2 reviews in total)
5/5 «This lotion saved my skin. Exfoliated in one swipe with no irritation. The product lasts a long time.»
5/5 «I love this product, does the job, I recommend it.»
What sets Filorga apart from all the marquess analyzed in this guide:
Please note: all Filorga products (except Huile Démaquillante) are fragranced. The textures are universally appreciated - sensoriality is a true signature. However, profiles that are hypersensitive to fragrances, or those undergoing active treatment on fragile skin, should be careful.
Morning: NCEF Essence - Hydra-Aox Serum - Time-Filler 5XP - SPF 50+
Evening: NCEF Essence - Sleep & Peel (2-3 evenings/week) OR Global-Repair Cream
Morning: Cleansing oil - NCEF Essence - Time-Filler 5XP - SPF 50+
Evening: Cleansing Oil - NCEF Essence - Global-Repair Cream
Morning: Age-Purify Cleansing Gel - Oxygen-Peel Lotion - SPF 50+
Evening: Oxygen-Peel Lotion (exfoliant) - Hydra-Aox Sérum
Can NCEF Serum replace retinol or vitamin C?
No - that's not its purpose. NCEF is designed as a cellular amplifier, not as a corrective asset in the strict sense. It increases available energy (ATP) to optimize the effectiveness of the other active ingredients. The logical order: retinol or vitamin C as the main corrective active ingredients, NCEF as a complement to boost their cellular environment.
Is Time Filler Essence suitable for sensitive skin?
Gluconolactone (PHA) is the best-tolerated exfoliant of all acid families - its high molecular weight slows penetration and reduces irritation. For daily use, even on sensitive profiles. On the other hand, the entire Filorga range is fragranced - if you're sensitive to fragrances in general, this remains a point of caution.
How to combine Sleep & Peel with other active ingredients?
Use 2-3 evenings/week maximum, alternating with retinol - never on the same evening (cumulative irritation). Other evenings: NCEF Essence + usual cream. The morning after a Sleep & Peel night: SPF 50+ mandatory. Do not use during pregnancy.
Are Filorga products compatible with pregnancy?
Time-Filler 5XP contains retinol - contraindicated during pregnancy and breastfeeding. Sleep & Peel (AHA) should be avoided as a precaution. NCEF Essence, Huile Démaquillante and Global-Repair Crème are generally considered compatible. Consult your doctor or midwife for any routine adjustments.
What is the BeautyDecoded application?
BeautyDecoded uses artificial intelligence to help you choose the right cosmetics for your skin type. The application analyzes INCI formulations and generates compatibility scores for 80 skin types. It is not a medical consultation, but rather a means of objectively selecting products according to a precise skin profile.
BeautyDecoded - The science of skin. Without marketing.
Information for educational purposes only. This information does not replace a medical consultation. Dr Sylvain David, Plastic Surgeon, Researcher and Youtuber.